SPS-4251
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $450 | Check With Us |
| 100mg | $750 | Check With Us |
| 200mg | $1125 | Check With Us |
: Cat #: V15184 CAS #: 870653-45-5 Purity ≥ 99%
Description: SPS-4251 [PAP-1; SPS4251; 5-(4-Phenoxybutoxy)psoralen] is a novel and potent KCNA3 channel blocker (inhibitor of Kv1.3, voltage-gated K+ channel) with the potential to be used in treatment of multiple sclerosis.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 350.37 |
|---|---|
| Molecular Formula | C21H18O5 |
| CAS No. | 870653-45-5 |
| Synonyms | SPS4251; SPS 4251; SPS-4251; PAP-1; SPS4251 |
| Protocol | In Vitro | PAP-1 (2-100 nM; 30 minutes) suppresses the proliferation of CCR7-TEM cells with IC50 of 10 nM |
|---|---|---|
| In Vivo | PAP-1 (0.3-3 mg/kg; i.p.; three times daily for 48 hours) prevents delayed type hypersensitivity (DTH) in lewis rats | |
| Animal model | 9- to 11- week-old female Lewis rats | |
| Dosages | Intraperitoneal injection; three times daily for 48 hours | |
| Administration | 0.3, 1, 3 mg/kg |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8541 mL | 14.2706 mL | 28.5413 mL | 57.0825 mL |
| 5mM | 0.5708 mL | 2.8541 mL | 5.7083 mL | 11.4165 mL |
| 10mM | 0.2854 mL | 1.4271 mL | 2.8541 mL | 5.7083 mL |
| 20mM | 0.1427 mL | 0.7135 mL | 1.4271 mL | 2.8541 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.