Amiodarone HCl (NSC 85442)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 10g | $150 | Check With Us |
| 100g | $700 | Check With Us |
| 200mg | $1050 | Check With Us |
: Cat #: V1672 CAS #: 19774-82-4 Purity ≥ 98%
Description: Amiodarone HCl (formerly NSC-85442; NSC85442; NSC 85442; Cordarone), the hydrochloride salt of amiodarone, is an antiarrhythmic drug used to treat and prevent an irregular heartbeat.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 681.77 |
|---|---|
| Molecular Formula | C25H29I2NO3.HCl |
| CAS No. | 19774-82-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 23 mg/mL (33.7 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 11 mg/mL (16.1 mM) | |
| Synonyms | NSC 85442; Amiodarone hydrochloride; NSC-85442; NSC85442; |
| Protocol | In Vivo | Long-term treatment of Amiodarone hydrochloride (90 and 180 mg/kg/day) induces dose-dependent remodeling of ion channel expression, which is associated with cardiac electrophysiological effects of Amiodarone hydrochloride |
|---|---|---|
| Animal model | Ten-week-old male C57BL/6 mice | |
| Dosages | 30, 90, and 180 mg/kg/day | |
| Administration | Treated orally; for 6 weeks |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.4668 mL | 7.3339 mL | 14.6677 mL | 29.3354 mL |
| 5mM | 0.2934 mL | 1.4668 mL | 2.9335 mL | 5.8671 mL |
| 10mM | 0.1467 mL | 0.7334 mL | 1.4668 mL | 2.9335 mL |
| 20mM | 0.0733 mL | 0.3667 mL | 0.7334 mL | 1.4668 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.