Dimethyl Fumarate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100g | $120 | Check With Us |
| 200g | $160 | Check With Us |
| 500g | $270 | Check With Us |
: Cat #: V13644 CAS #: 624-49-7 Purity ≥ 99%
Description: Dimethyl Fumarate (DMF, trade names Tecfidera; Skilarence), the methyl ester of fumaric acid, is a potent, orally bioactive and brain-penetrant immunomodulator and Nrf2 activator.
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| Molecular Weight (MW) | 144.13 |
|---|---|
| Molecular Formula | C6H8O4 |
| CAS No. | 624-49-7 |
| SMILES Code | O=C(OC)/C=C/C(OC)=O |
| Synonyms | Dimethyl Fumarate; Dimethylfumarate; DMF; |
| Protocol | In Vitro | Dimethyl fumarate induces necroptosis in colon cancer cells and the mechanism involves GSH depletion, an increase in ROS and activation of MAPKs-mediated signalling. Dimethyl fumarate (DMF; 100 μM; 3-24 hours) significantly activates JNK, p38 and ERK in CT26 cells. Dimethyl fumarate (DMF; 20-200 μM; 24 hours) treatment dose-dependently reduces the viability of SGC-7901, HT29, HCT116 and CT26 cancer cells. |
|---|---|---|
| In Vivo | Dimethyl fumarate (DMF; 50 mg/kg; oral gavage; daily; for 7 days) treatment is shown to upregulate the mRNA and protein levels of Nrf2 and Nrf2-regulated cytoprotective genes, attenuate 6-OHDA induced striatal oxidative stress and inflammation in C57BL/6 mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 6.9382 mL | 34.6909 mL | 69.3818 mL | 138.7636 mL |
| 5mM | 1.3876 mL | 6.9382 mL | 13.8764 mL | 27.7527 mL |
| 10mM | 0.6938 mL | 3.4691 mL | 6.9382 mL | 13.8764 mL |
| 20mM | 0.3469 mL | 1.7345 mL | 3.4691 mL | 6.9382 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.