4-Octyl Itaconate is a novel, potent and cell-permeable analog of itaconate, which is an emerging determinant of inflammation in activated macrophages and an anti-inflammatory metabolite that can activate Nrf2 (an anti-inflammatory transcription factorvia alkylation of KEAP1.

Brusatol (also known as NSC 172924; BRN 1444847), a naturally-occuring product isolated from the Brucea javanica plant, is a novel, potent and unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells and A549 xenografts to cisplatin and other chemotherapeutic drugs.

Dimethyl Fumarate (DMF, trade names Tecfidera; Skilarence), the methyl ester of fumaric acid, is a potent, orally bioactive and brain-penetrant immunomodulator and Nrf2 activator.

Sulforaphane (BroccoPhane; Detoxophane) is a naturally-occurring isothiocyanate widely found in consumed vegetables.