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Sulforaphane (BroccoPhane; Detoxophane)

This product is for research use only, not for human use. We do not sell to patients.

Sulforaphane (BroccoPhane; Detoxophane)
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Cat #: V10659 CAS #: 4478-93-7 Purity ≥ 98%

Description: Sulforaphane (BroccoPhane; Detoxophane) is a naturally-occurring isothiocyanate widely found in consumed vegetables.

References: Gamet-Payrastre L, et al. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res. 2000 Mar 1;60(5):1426-33.

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Molecular Weight (MW)C6H11NOS2
Molecular Formula177.29
CAS No.4478-93-7
SMILES CodeO=S(CCCCN=C=S)C 
SynonymsSulforaphane; BroccoPhane; Detoxophane; Sulphoraphane; Broccoli sprout extracts; 4-methyl-sulfinybutyl isothiocyanatel; Sulforafan;
ProtocolIn VitroSulforaphane induces a cell cycle arrest in a dose-dependent manner, followed by cell death. This sulforaphane-induced cell cycle arrest was correlated with an increased expression of cyclins A and B1. Sulforaphane induces cell death via an apoptotic process. Sulforaphane inhibits the reinitiation of growth and diminishes cellular viability in quiescent colon carcinoma cells (HT29) and has a lower toxicity on differentiated CaCo2 cells.
In VivoSulforaphane can block the formation of ammary tumors in Sprague-Dawley rats treated with single doses of 9,10-dimethyl-1,2-benzanthracene. Administration of sulforaphane reduces the incidence, multiplicity, and weights and delays the development of the mammary tumors evoked by a single dose of DMBA in female Sprague-Dawley rats.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Quality Control Documentation
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Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
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