Tiaprofenic acid

This product is for research use only, not for human use. We do not sell to patients.

Tiaprofenic acid
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Size Price Stock
2g$480Check With Us
5g$880Check With Us
10g$1320Check With Us

Cat #: V16407 CAS #: 33005-95-7 Purity ≥ 98%

Description: Tiaprofenic acid (Surgam, Surgamyl and Tiaprofen) is a non-steroidal anti-inflammatory drug (NSAID) approved for the treatment of pain, especially arthritic pain.

References: G L Plosker, et al. Tiaprofenic Acid. A Reappraisal of Its Pharmacological Properties and Use in the Management of Rheumatic Diseases. Drugs. 1995 Dec;50(6):1050-75.

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Molecular Weight (MW)260.31
Molecular FormulaC14H12O3S
CAS No.33005-95-7
SMILES CodeCC(C1=CC=C(C(C2=CC=CC=C2)=O)S1)C(O)=O
SynonymsTiaprofenic acid; trade names Surgam, Surgamyl and Tiaprofen.
ProtocolIn VivoFemale Lewis rats received either Tiaprofenic acid (as an intravenous (iv.) bolus injection of 15 mg/kg and constant infusion of 0.02 mg/min) for 6 h. Tiaprofenic acid results in a significant decrease in serum sulfate concentrations and increase in sulfate clearance ratio. There is also a significant decrease in the fraction of sulfate reabsorbed by the kidneys.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.8416 mL19.2079 mL38.4157 mL76.8315 mL
5mM0.7683 mL3.8416 mL7.6831 mL15.3663 mL
10mM0.3842 mL1.9208 mL3.8416 mL7.6831 mL
20mM0.1921 mL0.9604 mL1.9208 mL3.8416 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.