ICA-121431
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $750 | Check With Us |
| 500mg | $1250 | Check With Us |
| 1g | $1875 | Check With Us |
: Cat #: V2997 CAS #: 313254-51-2 Purity ≥ 98%
Description: ICA-121431 is a potent, highly selective small molecule inhibitor of the human Nav1.3 and Nav1.1 voltage gated sodium channels with IC50 of 19 nM.
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| Molecular Weight (MW) | 449.54 |
|---|---|
| Molecular Formula | C23H19N3O3S2 |
| CAS No. | 313254-51-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 40 mg/mLr |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | O=C(NC1=CC=C(S(=O)(NC2=NC=CS2)=O)C=C1)C(C3=CC=CC=C3)C4=CC=CC=C4 |
| Synonyms | ICA-121431; ICA 121431; ICA121431. |
| Protocol | In Vitro | ICA-121431 interacts with human Nav1.3 and the amino acid residues that may define selectivity for this channel over other related Nav channels, including Nav1.7 and Nav 1.5. Data generated using conventional patch clamp electrophysiological recording using a pulse protocol whereby a 20-ms test pulse is preceded by an 8-s step to a voltage that inactivated half of the channels |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2245 mL | 11.1225 mL | 22.2450 mL | 44.4899 mL |
| 5mM | 0.4449 mL | 2.2245 mL | 4.4490 mL | 8.8980 mL |
| 10mM | 0.2224 mL | 1.1122 mL | 2.2245 mL | 4.4490 mL |
| 20mM | 0.1112 mL | 0.5561 mL | 1.1122 mL | 2.2245 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
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mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.