Procaine HCl (Novocaine)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 10g | $160 | Check With Us |
| 100g | $800 | Check With Us |
| 200g | $1200 | Check With Us |
: Cat #: V1666 CAS #: 51-05-8 Purity ≥ 98%
Description: Procaine HCl (also known as Novocaine; Gerovital H3; Aminocaine), the HCl salt of Procaine, is a local anesthetic that acts as an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM.
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| Molecular Weight (MW) | 272.77 |
|---|---|
| Molecular Formula | C13H20N2O2.HCl |
| CAS No. | 51-05-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 55 mg/mL (201.6 mM)r |
| Water: 55 mg/mL (201.6 mM)r | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | Chemical Name: 2-(diethylamino)ethyl 4-aminobenzoate;hydrochloride InChi Key: HCBIBCJNVBAKAB-UHFFFAOYSA-N InChi Code: InChI=1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H SMILES Code: CCN(CC)CCOC(=O)C1=CC=C(C=C1)N.Cl |
| Synonyms | Novocaine HCl; Procaine Hydrochloride; Procaine HCl; Novocaine hydrochloride; Gerovital H3; Aminocaine |
| Protocol | In Vitro | Procaine hydrochloride (0.01-100 microM) inhibited the 5-HT3 receptor-mediated inward current in the whole-cell patch clamp recording. Procaine appears to produce a competitive inhibition on 5-HT3 receptors with a KD of 1.7 microM |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.6661 mL | 18.3305 mL | 36.6609 mL | 73.3218 mL |
| 5mM | 0.7332 mL | 3.6661 mL | 7.3322 mL | 14.6644 mL |
| 10mM | 0.3666 mL | 1.8330 mL | 3.6661 mL | 7.3322 mL |
| 20mM | 0.1833 mL | 0.9165 mL | 1.8330 mL | 3.6661 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
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Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.