QX-314 Br
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $500 | Check With Us |
| 250mg | $950 | Check With Us |
| 500mg | $1425 | Check With Us |
: Cat #: V13541 CAS #: 24003-58-5 Purity ≥ 98%
Description: QX-314 Br is a novel intracellular blocker of NaV channels1-4 and a membrane impermeable quaternary analogue of lidocaine, a blocker of voltage-activated Na+ channels.
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- Related Biological Data
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| Molecular Weight (MW) | 343.30 |
|---|---|
| Molecular Formula | C16H27BrN2O |
| CAS No. | 24003-58-5 |
| SMILES Code | CC[N+](CC)(CC(NC1=C(C)C=CC=C1C)=O)CC.[Br-] |
| Synonyms | QX-314 Br; QX-314Br; QX314 Br; QX 314 |
| Protocol | In Vivo | QX-314 bromide (1.6 mg/kg; i.c.) abolishes responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin |
|---|---|---|
| Animal model | Male Sprague-Dawley rats (250-290 g) | |
| Dosages | 1.6 mg/kg | |
| Administration | Intracutaneous injection |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9129 mL | 14.5645 mL | 29.1290 mL | 58.2581 mL |
| 5mM | 0.5826 mL | 2.9129 mL | 5.8258 mL | 11.6516 mL |
| 10mM | 0.2913 mL | 1.4565 mL | 2.9129 mL | 5.8258 mL |
| 20mM | 0.1456 mL | 0.7282 mL | 1.4565 mL | 2.9129 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.