Ambroxol HCl (NA-872)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
2g	$200	Check With Us
10g	$600	Check With Us
20g	$900	Check With Us

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Cat #: V1661 CAS #: 23828-92-4 Purity ≥ 98%

Description: Ambroxol HCl (formerly NA872; NA 872; Abrohexal; Ebromin; Ambril; Ambro-Puren Ambrobeta; Duramucal; Mucosolvan), the hydrochloride salt of ambroxol, is a secretolytic agent that has been used in the treatment of respiratory diseases associated with viscid or excessive mucus.

References: Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov; 80(5):766-775.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	414.56
Molecular Formula	C13H18Br2N2O.HCl
CAS No.	23828-92-4
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 4 mg/mL (9.6 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Synonyms	NA-872; Abrohexal; Duramucal; Ebromin; Ambril; NA872; NA 872; Ambro-Puren Ambrobeta; Mucosolvan

Protocol	In Vivo	Ambroxol hydrochloride (NA-872 hydrochloride； 12, 1, 3, 4 mM in drinking water for 5 consecutive days) resulted in increased brain glucocerebrosidase activity in wild-type mice, transgenic mice expressing heterozygous L1P mutations in the mouse glucocerebrosidase 444 gene, and transgenic mice overexpressing human α-synuclein

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4122 mL	12.0610 mL	24.1220 mL	48.2439 mL
5mM	0.4824 mL	2.4122 mL	4.8244 mL	9.6488 mL
10mM	0.2412 mL	1.2061 mL	2.4122 mL	4.8244 mL
20mM	0.1206 mL	0.6030 mL	1.2061 mL	2.4122 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.