Proparacaine HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$199	Check With Us
2g	$290	Check With Us
5g	$455	Check With Us

: [email protected] [email protected]

Cat #: V1653 CAS #: 5875-06-9 Purity ≥ 98%

Description: Proparacaine HCl (Proxymetacaine; Proxymetacaine), the hydrochloride salt of proparacaine, is a voltage-gated sodium channels antagonist approved as an ophthalmic solution for topical anesthetic use in ophthalmic practice.

References:

Hwan Soo Kim, et al. Effect of Proparacaine in a Mouse Model of Allergic Rhinitis. Clin Exp Otorhinolaryngol. 2017 Dec; 10(4): 325–331.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	330.85
Molecular Formula	C16H26N2O3.HCl
CAS No.	5875-06-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 12 mg/mL (36.3 mM)r
	Water: 66 mg/mL (199.5 mM)r
	Ethanol: <1 mg/mL
Solubility In Vivo	Saline: 30 mg/mL
Synonyms	Proxymetacaine; Proxymetacaine

Protocol	In Vivo	Proparacaine Hydrochloride (75 μg/30 μL; intranasal administration; for 7 days) significantly decreases nasal symptoms, number of eosinophils, goblet cells, and mast cells in the lamina propria of the nasal mucosa
	Animal model	7-week-old female BALB/c mice, allergic rhinitis model
	Dosages	75 μg/30 μL
	Administration	Intranasal administration, for 7 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.0225 mL	15.1126 mL	30.2252 mL	60.4504 mL
5mM	0.6045 mL	3.0225 mL	6.0450 mL	12.0901 mL
10mM	0.3023 mL	1.5113 mL	3.0225 mL	6.0450 mL
20mM	0.1511 mL	0.7556 mL	1.5113 mL	3.0225 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.