CRMP2-Ubc9-NaV1.7 inhibitor 194
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1950 | Check With Us |
| 1g | $3200 | Check With Us |
| 5g | $8640 | Check With Us |
: Cat #: V2531 CAS #: 2241651-99-8 Purity ≥ 99%
Description: CRMP2-Ubc9-NaV1.7 inhibitor 194 can prevent the SUMOylation of the NaV1.7-interacting protein CRMP2 and reduce NaV1.7 surface expression as well as current density.
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| Molecular Weight (MW) | 567.63 |
|---|---|
| Molecular Formula | C34H31F2N3O3 |
| CAS No. | 2241651-99-8 |
| Protocol | In Vivo | AZ194 would provide pain relief in rat models of chemotherapy- and nerve injury- induced neuropathic pain. AZ194 (orally; at 2 and 10 mg/kg) restores mechanical sensitivity in animals with chemotherapy-induced and nerve injury-induced neuropathic nociception |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7617 mL | 8.8086 mL | 17.6171 mL | 35.2342 mL |
| 5mM | 0.3523 mL | 1.7617 mL | 3.5234 mL | 7.0468 mL |
| 10mM | 0.1762 mL | 0.8809 mL | 1.7617 mL | 3.5234 mL |
| 20mM | 0.0881 mL | 0.4404 mL | 0.8809 mL | 1.7617 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.