PF-05089771
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $2200 | Check With Us |
| 250mg | $3450 | Check With Us |
| 500mg | $5175 | Check With Us |
: Cat #: V2967 CAS #: 1235403-62-9 Purity ≥ 98%
Description: PF-05089771 (PF05089771) is a potent and subtype selective NaV1.7 inhibitor (IC50 = 11 nM) and Nav1.8 voltage-gated sodium channel blocker with the potential to be used in the treatment of chronic neuropathic pain.
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| Molecular Weight (MW) | 500.34 |
|---|---|
| Molecular Formula | C18H12Cl2FN5O3S2 |
| CAS No. | 1235403-62-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: >35 mg/mLr |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Synonyms | PF05089771; PF 05089771; PF-05089771 |
| Protocol | In Vitro | PF-05089771 is determined to be more than 1000-fold selective over tetrodotoxin-resistant (TTX-R) Nav1.5 and Nav1.8 channels (IC50s >10 μM) and exhibited a range of selectivity over TTX-sensitive (TTX-S) channels (10-fold for Nav1.2 to 900-fold for Nav1.3 and Nav1.4) |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9986 mL | 9.9932 mL | 19.9864 mL | 39.9728 mL |
| 5mM | 0.3997 mL | 1.9986 mL | 3.9973 mL | 7.9946 mL |
| 10mM | 0.1999 mL | 0.9993 mL | 1.9986 mL | 3.9973 mL |
| 20mM | 0.0999 mL | 0.4997 mL | 0.9993 mL | 1.9986 mL |
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The dilution calculator equation
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.