Ibutilide Fumarate (U70226E)

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
500mg	$550	Check With Us
1g	$900	Check With Us
5g	$2440	Check With Us

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Cat #: V1663 CAS #: 122647-32-9 Purity ≥ 98%

Description: Ibutilide fumarate (formerly known as U 70226 E; U-70226-E; U-70226E), the fumarate salt of Ibutilide, is a Class III antiarrhythmic agent that has been used for treating acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current.

References: Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent effects. Circulation. 1995 Mar 15;91(6):1799-806.

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Physicochemical and Storage Information
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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	885.23
Molecular Formula	(C20H36N2O3S)2.C4H4O4
CAS No.	122647-32-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 89 mg/mL (100.5 mM)r
	Water: 89 mg/mL (100.5 mM)r
	Ethanol: 89 mg/mL (100.5 mM)
Synonyms	U70226E; U 70226E; U70226 E; U 70226 E; U-70226-E; U-70226E

Protocol	In Vitro	Ibutilide fumarate is a potent IKr blocker with an EC50 value of 20 nM at +20 mV in atrial tumor myocytes (AT-1) cells
	In Vivo	Ibutilide fumarate prolongs cardiac repolarization in vitro and in vivo
	Animal model	Fifteen adult mongrel dogs of either sex
	Dosages	0.01, 0.02 and 0.05 mg/kg
	Administration	Intravenous injection; each as a 10-min infusion

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.1296 mL	5.6482 mL	11.2965 mL	22.5930 mL
5mM	0.2259 mL	1.1296 mL	2.2593 mL	4.5186 mL
10mM	0.1130 mL	0.5648 mL	1.1296 mL	2.2593 mL
20mM	0.0565 mL	0.2824 mL	0.5648 mL	1.1296 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.