SM-324405
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1115 | To Be Confirmed |
| 200mg | $1670 | To Be Confirmed |
| 500mg | $2820 | To Be Confirmed |
: Cat #: V5846 CAS #: 677773-91-0 Purity ≥ 99%
Description: SM-324405 (SM324405; SM 324405) is a novel and potent TLR7 (toll-like receptor 7) agonist designed by introducing the antedrug concept with reduced systemic activity.
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| Molecular Weight (MW) | 385.42 |
|---|---|
| Molecular Formula | C19H23N5O4 |
| CAS No. | 677773-91-0 |
| SMILES Code | O=C(OC)CC1=CC=CC(CN2C(NC3=C(N)N=C(OCCCC)N=C23)=O)=C1 |
| Synonyms | SM-324405; SM324405; SM 324405; |
| Protocol | In Vitro | SM-324405 is a novel candidate for immunotherapy of allergic diseases. |
|---|---|---|
| In Vivo | SM-324405 is metabolized to the corresponding acid in human plasma with t1/2 of 2.6 min. SM-324405 (9e, intratracheal administration) effectively inhibits allergen-induced airway inflammation without inducing cytokines systemically. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5946 mL | 12.9729 mL | 25.9457 mL | 51.8914 mL |
| 5mM | 0.5189 mL | 2.5946 mL | 5.1891 mL | 10.3783 mL |
| 10mM | 0.2595 mL | 1.2973 mL | 2.5946 mL | 5.1891 mL |
| 20mM | 0.1297 mL | 0.6486 mL | 1.2973 mL | 2.5946 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.