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Size | Price | Stock |
---|---|---|
250mg | $800 | Check With Us |
500mg | $1250 | Check With Us |
1g | $1875 | Check With Us |
Cat #: V12297 CAS #: 1159600-41-5 Purity ≥ 98%
Description: Basmisanil, formerly known as RG1662, RO5186582, is a highly selective inverse agonist/negative allosteric modulator of α5 subunit-containing GABAA receptors which is under development by Roche for the treatment of cognitive impairment associated with Down syndrome.
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Molecular Weight (MW) | 445.4654 |
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Molecular Formula | C21H20FN3O5S |
CAS No. | 1159600-41-5 |
Synonyms | RG 1662; RG-1662; RG1662; RO5186582; RO-5186582; RO 5186582; Basmisanil. |
Protocol | In Vitro | Basmisanil (0.1 nM-100 μM) has high affinity for bounding to recombinant human GABAA-α5 receptors with a Ki value of 5 nM and more than 90-fold selectivity versus α1 (Ki = 1031 nM), α2 (Ki = 458 nM), and α3 (Ki = 510 nM) subunit-containing receptors |
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In Vivo | Basmisanil (3-600 mg/kg p.o.) improves cognition in rats and non.human primates and not show anxiogenic or proconvulsant effects | |
Animal model | Sprague Dawley rats(180 g; female) | |
Dosages | 3-100 mg/kg |
Solvent volume to be added | Mass (the weight of a compound) | |||
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Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
1mM | 2.2448 mL | 11.2242 mL | 22.4484 mL | 44.8969 mL |
5mM | 0.4490 mL | 2.2448 mL | 4.4897 mL | 8.9794 mL |
10mM | 0.2245 mL | 1.1224 mL | 2.2448 mL | 4.4897 mL |
20mM | 0.1122 mL | 0.5612 mL | 1.1224 mL | 2.2448 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.