SR-717 lithium
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $750 | Check With Us |
| 250mg | $1280 | Check With Us |
| 500mg | $1920 | Check With Us |
: Cat #: V2205 CAS #: 2375421-09-1 Purity ≥ 98%
Description: SR-717 lithium is a novel, potent and non-nucleotide STING (stimulator of interferon genes) agonist with anticancer activities.
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| Molecular Weight (MW) | 351.19 |
|---|---|
| Molecular Formula | C15H8F2LiN5O3 |
| CAS No. | 2375421-09-1 |
| SMILES Code | O=C([O-])C1=CC(F)=C(F)C=C1NC(C2=NN=C(N3C=CN=C3)C=C2)=O.[Li+] |
| Synonyms | SR-717 lithium; SR 717 lithium; SR717 lithium |
| Protocol | In Vitro | SR-717 (3.8 μM) induces the expression of PD-L1 in THP1 cells and in primary human peripheral blood mononuclear cells in a STING-dependent manner. SR-717 activates STING by inducing the same closed conformation, which thereby provides an avenue to explore this class of systemic STING agonist in diverse contexts, including antitumor immunity. |
|---|---|---|
| In Vivo | SR-717 (30 mg/kg intraperitoneally for 7 days) displays antitumor activity; promots the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitates antigen cross-priming. SR-717 (30 mg/kg intraperitoneal once-per-day for 1 week) shows antitumor activities in WT or Stinggt/gt mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8475 mL | 14.2373 mL | 28.4746 mL | 56.9492 mL |
| 5mM | 0.5695 mL | 2.8475 mL | 5.6949 mL | 11.3898 mL |
| 10mM | 0.2847 mL | 1.4237 mL | 2.8475 mL | 5.6949 mL |
| 20mM | 0.1424 mL | 0.7119 mL | 1.4237 mL | 2.8475 mL |
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Step Two: Enter the in vivo formulation
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Method for preparing DMSO master liquid:
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.