STING inhbitor 1
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $2150 | Check With Us |
| 1g | $3100 | Check With Us |
| 5g | $7840 | Check With Us |
: Cat #: V2457 CAS #: 727699-84-5 Purity ≥ 99%
Description: STING inhbitor 1 is a novel and potent inhibitor of STING, which inhibits the activation of Sting signaling pathway.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 476.52 |
|---|---|
| Molecular Formula | C26H21FN2O4S |
| CAS No. | 727699-84-5 |
| SMILES Code | O=C(C1=CC=C(C2=CC=CC=C2)C=C1)NC3=CC=C(OC)C(NS(=O)(C4=CC=C(F)C=C4)=O)=C3 |
| Synonyms | DUN99845; DUN-99845; DUN 99845; |
| Protocol | In Vitro | SN-001 (10 μM; 3 h) inhibits cytosolic DNA-triggered STING signaling. SN-001 (5-20 μM; 6 h) significantly impairs the induction of Ifnb mRNA, in a dose-dependent manner in L929 cells. SN-001 targets the cyclic dinucleotide binding pocket of human STING. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0985 mL | 10.4927 mL | 20.9855 mL | 41.9710 mL |
| 5mM | 0.4197 mL | 2.0985 mL | 4.1971 mL | 8.3942 mL |
| 10mM | 0.2099 mL | 1.0493 mL | 2.0985 mL | 4.1971 mL |
| 20mM | 0.1049 mL | 0.5246 mL | 1.0493 mL | 2.0985 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.