C-176 | CAS 314054-00-7

C-176

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$620	In Stock
500mg	$1050	In Stock
1g	$1575	In Stock

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Cat #: V3831 CAS #: 314054-00-7 Purity ≥ 98%

Description: C-176 is a highly potent, covalent/irreversible and selective small-molecule antagonist/inhibitor of the stimulator of interferon genes (STING) protein, which is a central signalling component of the intracellular DNA sensing pathway.

References: Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	358.09
Molecular Formula	C11H7IN2O4
CAS No.	314054-00-7
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10 mMr
	Water: < 1 mg/mLr
	Ethanol: < 1 mg/mL
SMILES Code	O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(I)C=C2
Synonyms	C-176, C176; C 176; STING inhibitor C-176; STING inhibitor I

Protocol	In Vitro	C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6.
Protocol	In Vivo	C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1−/− mice. C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1−/− mice. C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.7926 mL	13.9630 mL	27.9259 mL	55.8519 mL
5mM	0.5585 mL	2.7926 mL	5.5852 mL	11.1704 mL
10mM	0.2793 mL	1.3963 mL	2.7926 mL	5.5852 mL
20mM	0.1396 mL	0.6981 mL	1.3963 mL	2.7926 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.