MSA-2
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1750 | Check With Us |
| 1g | $2850 | Check With Us |
| 5g | $7210 | Check With Us |
: Cat #: V2470 CAS #: 129425-81-6 Purity ≥ 98%
Description: MSA 2 (MSA2; MSA-2) is a novel, orally bioactive and potent non-nucleotide agonist of stimulator of interferon genes (STING) with potential antitumor activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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| Molecular Weight (MW) | 294.32 |
|---|---|
| Molecular Formula | C14H14O5S |
| CAS No. | 129425-81-6 |
| SMILES Code | COC1=CC2=C(C=C(S2)C(CCC(O)=O)=O)C=C1OC |
| Synonyms | MSA 2; MSA2; MSA-2; |
| Protocol | In Vivo | MSA-2 (PO: 60 mg/kg or SC: 50 mg/kg; single dose) that effectively inhibits tumor growth induced substantial elevations of IFN-β, interleukin-6 (IL-6), and TNF-α in tumor. MSA-2 dosed via either PO or SC regimens achieved comparable exposure in both tumor and plasma. MSA-2 also exhibits dose-dependent antitumor activity when administered by IT, SC, or PO routes, and dosing regimens were identified that induced complete tumor regressions in 80 to 100% of treated animals. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.3977 mL | 16.9883 mL | 33.9766 mL | 67.9532 mL |
| 5mM | 0.6795 mL | 3.3977 mL | 6.7953 mL | 13.5906 mL |
| 10mM | 0.3398 mL | 1.6988 mL | 3.3977 mL | 6.7953 mL |
| 20mM | 0.1699 mL | 0.8494 mL | 1.6988 mL | 3.3977 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.