Triclabendazole (CGA89317)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$350	Check With Us
2g	$550	Check With Us
5g	$860	Check With Us

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Cat #: V1624 CAS #: 68786-66-3 Purity ≥ 98%

Description: Triclabendazole (also known as CGA-89317; CGA89317; EGA-230B; Fasinex; NVP-EGA-230; Egaten) is a benzimidazole-based anthelmintic and fasciolicidal agent that acts as a tubulin inhibitor by binding to tubulin and impairing the intracellular transport mechanisms, thus interfering with protein synthesis.

References: Moll, L., et al., Resistance of Fasciola hepatica against triclabendazole in cattle and sheep in The netherlands. Vet Parasitol, 2000. 91(1-2): p. 153-8.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	359.66
Molecular Formula	C14 H9Cl3N2OS
CAS No.	68786-66-3
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 72 mg/mL (200.2 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Synonyms	CGA 89317; EGA230B; NVP-EGA230; CGA-89317; EGA-230B; NVP-EGA 230; CGA89317; EGA 230B; Fasinex; NVP-EGA-230; Egaten.

Protocol	Animal model

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.7804 mL	13.9020 mL	27.8040 mL	55.6081 mL
5mM	0.5561 mL	2.7804 mL	5.5608 mL	11.1216 mL
10mM	0.2780 mL	1.3902 mL	2.7804 mL	5.5608 mL
20mM	0.1390 mL	0.6951 mL	1.3902 mL	2.7804 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.