Combretastatin A4 (CA-4; CRC 87-09)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $680 | Check With Us |
| 1g | $980 | Check With Us |
| 5g | $2646 | Check With Us |
: Cat #: V1610 CAS #: 117048-59-6 Purity ≥ 98%
Description: Combretastatin A4 (CA-4; CRC-87-09; Combretastatin A-4) is a highly potent tubulin/microtubule inhibitor or microtubule polymerization destablizer with potential antitumor activity.
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| Molecular Weight (MW) | 316.35 |
|---|---|
| Molecular Formula | C18H20O5 |
| CAS No. | 117048-59-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 63 mg/mL (199.1 mM)r |
| Water:<1 mg/mLr | |
| Ethanol: 34 mg/mL (107.5 mM) | |
| Solubility In Vivo | 5% DMSO+50% PEG 300+ddH2O: 30mg/mL |
| Synonyms | Combretastatin A-4; Combretastatin A4; CRC 87-09; Combretastatin A 4; CA-4; CRC 87-09; CA4; CRC 87-09; CA 4; |
| Protocol | In Vivo | DBP and MBP at 30 minutes after administration are higher in rats treated with Combretastatin A4 disodium phosphate 120 mg/10 mL/kg. The toxicokinetic parameters of Combretastatin A4 phosphate and Combretastatin A4 in rats treated with Combretastatin A4 disodium phosphate 120 mg/10 mL/kg are indicated, and the values of Cmax, T1/2, and AUC0-inf for Combretastatin A4 are 156±13 μM, 5.87±1.69 h, and 89.4±10.1 h·μM, respectively |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.1611 mL | 15.8053 mL | 31.6106 mL | 63.2211 mL |
| 5mM | 0.6322 mL | 3.1611 mL | 6.3221 mL | 12.6442 mL |
| 10mM | 0.3161 mL | 1.5805 mL | 3.1611 mL | 6.3221 mL |
| 20mM | 0.1581 mL | 0.7903 mL | 1.5805 mL | 3.1611 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.