Nocodazole (Oncodazole; R17934)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$750	Check With Us
1g	$1125	Check With Us
5g	$3035	Check With Us

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Cat #: V1608 CAS #: 31430-18-9 Purity ≥ 98%

Description: Nocodazole (Oncodazole; R-17934; R17934) is a potent and rapidly-reversible inhibitor of microtubule polymerization/microtubule destablizer, the so called antimitotic or antitubulin agent, with potential antineoplastic activity.

References: Keliang Xu, et al. Interaction of nocodazole with tubulin isotypes. Drug Development Research 2002

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	301.32
Molecular Formula	C14H11N3O3S
CAS No.	31430-18-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 7 mg/mL (23.2 mM)r
	Water:<1 mg/mLr
	Ethanol: <1 mg/mL
Solubility In Vivo	1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL
Synonyms	R-17934; Oncodazole; R 17934; R17934

Protocol	In Vitro	Nocodazole exhibits good affinity toward c-KIT, with a Kd value of 1.6 μM in highly malignant human cancer cells. Nocodazole displays good binding affinity toward the components of the mitogen-activated protein kinase (MAPK) pathway, such as BRAF (Kd=1.8 μM), BRAF(V600E) (Kd=1.1 μM), MEK1 (Kd=1.7 μM), and MEK2 (Kd=1.6 μM)[1]. Nocodazole has the highest affinity for αβIV and the lowest affinity for αβIII

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.3187 mL	16.5937 mL	33.1873 mL	66.3746 mL
5mM	0.6637 mL	3.3187 mL	6.6375 mL	13.2749 mL
10mM	0.3319 mL	1.6594 mL	3.3187 mL	6.6375 mL
20mM	0.1659 mL	0.8297 mL	1.6594 mL	3.3187 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.