GNE-6776 HCl | CAS 2009273-60-1

GNE-6776 HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$1190	To Be Confirmed
250mg	$2050	To Be Confirmed
500mg	$3075	To Be Confirmed

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Cat #: V3859 CAS #: 2009273-60-1 Purity ≥ 98%

Description: GNE-6776 HCl (GNE6776), the hydrochloride salt of GNE-6776 which is an analog of GNE-6640, is a novel potent and selective inhibitor of USP7 (ubiquitin-specific protease-7) with potential anticancer activity.

References: Robert Blake, et al. Usp7 inhibitor compounds and methods of use. US20160272588A1.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	348.41
Molecular Formula	C20H20N4O2
CAS No.	2009273-60-1
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: ≥ 300 mg/mLr
	Water: N/Ar
	Ethanol: N/A
SMILES Code	O=C(C1=CC=C(C2=C(CC)C(C3=CC=C(O)C=C3)=C(N)N=C2)C=N1)NC
Synonyms	GNE-6776; GNE 6776; GNE6776

Protocol	In Vitro	USP7 or HAUSP (herpesvirus-associated USP) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. USP7 is a eubiquitinase (DUB) that controls cell proliferation by altering the stability of Mdm2, p53, PTEN and FOXO4.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.8702 mL	14.3509 mL	28.7018 mL	57.4036 mL
5mM	0.5740 mL	2.8702 mL	5.7404 mL	11.4807 mL
10mM	0.2870 mL	1.4351 mL	2.8702 mL	5.7404 mL
20mM	0.1435 mL	0.7175 mL	1.4351 mL	2.8702 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.