MRT68921
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $450 | Check With Us |
| 250mg | $850 | Check With Us |
| 500mg | $1275 | Check With Us |
: Cat #: V26017 CAS #: 1190379-70-4 Purity ≥ 99%
Description: MRT-68921 (MRT68921; MRT 68921) is a novel, potent and dual inhibitor of the autophagy kinase ULK1 and ULK2 with IC50s of 2.9 and 1.1 nM, respectively.
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| Molecular Weight (MW) | 434.58 |
|---|---|
| Molecular Formula | C25H34N6O |
| CAS No. | 1190379-70-4 |
| SMILES Code | O=C(C1CCC1)NCCCNC2=CC(NC3=CC4=C(CN(C)CC4)C=C3)=CC=C2C5CC5 |
| Synonyms | MRT68921; MRT-68921; MRT 68921; MRT68921 free base |
| Protocol | In Vitro | ULK1, a serine/threonine protein kinase, is essential for the initial stages of autophagy. MRT68921 inhibits ULK1 and ULK2 in vitro and block autophagy in cells. MRT68921 is the most potent inhibitor of both ULK1 and ULK2, with greater than a 15-fold reduction in the IC50 for ULK1 (2.9 nm) and greater than a 30-fold reduction for ULK2 (1.1 nm). Autophagy-inhibiting capacity of the compounds is specifically through ULK1. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3011 mL | 11.5054 mL | 23.0107 mL | 46.0214 mL |
| 5mM | 0.4602 mL | 2.3011 mL | 4.6021 mL | 9.2043 mL |
| 10mM | 0.2301 mL | 1.1505 mL | 2.3011 mL | 4.6021 mL |
| 20mM | 0.1151 mL | 0.5753 mL | 1.1505 mL | 2.3011 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.