LYN-1604 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1150 | Check With Us |
| 500mg | $1650 | Check With Us |
| 5g | $2475 | Check With Us |
: Cat #: V3196 CAS #: 2216753-86-3 Purity ≥ 98%
Description: LYN-1604 HCl, the hydrochloride salt of LYN-1604, is a novel and potent activator/agonist of the UNC-51-like kinase 1 (ULK1) (EC50 = 18.94 nM) with anticancer activity.
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| Molecular Weight (MW) | 621.08 |
|---|---|
| Molecular Formula | C₃₃H₄₄Cl₃N₃O₂ |
| CAS No. | 2216753-86-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: >100 mg/mLr |
| Water: NAr | |
| Ethanol: NA | |
| SMILES Code | ClC1=CC=C(C(CN2CCN(C(CN(CC(C)C)CC(C)C)=O)CC2)OCC3=CC=C(C=CC=C4)C4=C3)C(Cl)=C1.[H]Cl |
| Synonyms | LYN1604 HCl; LYN 1604 HCl; LYN-1604 HCl |
| Protocol | In Vitro | LYN-1604 can also increase cleavage of caspase3 and induce apoptosis. LYN-1604 induces ATG5-dependent autophagy via the ULK complex. LYN-1604 (0.5-2 μM, 24 hours) induces remarkable up-regulation of Beclin-1 and degradation of p62, as well as transformation of LC3-I to LC3-II in MDA-MB-231 cells. LYN-1604 (0.5, 1.0 and 2.0 μM) induces cell death via the ULK complex in MDA-MB-231 cells. LYN-1604 binds to wild-type ULK1 with a binding affinity in the nanomole range (KD=291.4 nM) . LYN-1604 is a potential ULK1 agonist (enzymatic activity=195.7% at 100 nM and IC50=1.66 μM against MDA-MB-231 cells) . |
|---|---|---|
| In Vivo | LYN-1604 (low dose, 25 mg/kg; median dose, 50 mg/kg; high dose, 100 mg/kg; intragastric administration once a day for 14 days) inhibits the growth of xenograft TNBC by targeting ULK1-modulated cell death. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.6101 mL | 8.0505 mL | 16.1010 mL | 32.2020 mL |
| 5mM | 0.3220 mL | 1.6101 mL | 3.2202 mL | 6.4404 mL |
| 10mM | 0.1610 mL | 0.8050 mL | 1.6101 mL | 3.2202 mL |
| 20mM | 0.0805 mL | 0.4025 mL | 0.8050 mL | 1.6101 mL |
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