METFORMIN HCL
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100g | $245 | Check With Us |
| 200g | $445 | Check With Us |
| 500mg | $750 | Check With Us |
: Cat #: V2532 CAS #: 1115-70-4 Purity ≥ 98%
Description: Metformin HCl is a hypoglycemic medication used in the treatment of type 2 diabetes (non-insulin-dependent diabetes mellitus).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 165.62 |
|---|---|
| Molecular Formula | C4H11N5.HCl |
| CAS No. | 1115-70-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 33 mg/mL (199.3 mM)r |
| Water: 33 mg/mL (199.3 mM)r | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | Chemical Name: 1,1-Dimethylbiguanide hydrochloride InChi Key: OETHQSJEHLVLGH-UHFFFAOYSA-N InChi Code: InChI=1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H SMILES Code: N=C(NC(N)=N)N(C)C.[H]Cl |
| SMILES Code | N=C(NC(N)=N)N(C)C.[H]Cl |
| Synonyms | 1,1-Dimethylbiguanide hydrochloride; ADX-155; EFB-0027; EX-404; La-6023; SMP-862; ADX 155; EFB 0027; EX 404; La 6023; SMP 862; ADX155; EFB0027; EX404; La6023; SMP862; Fortamet |
| Protocol | In Vitro | Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) inhibits proliferation of ESCs in a concentration-dependent manner. The IC50 is 2.45 mM for A-ESCs and 7.87 mM for N-ESCs. Metformin shows pronounced effects on activation of AMPK signaling in A-ESCs from secretory phase than in cells from proliferative phase. |
|---|---|---|
| In Vivo | Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride; 100 mg/kg, p.o.) alone, and metformin (25, 50, 100 mg/kg) with NSC 37745 groups attenuates myocyte necrosis through histopathological analysis. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 6.0379 mL | 30.1896 mL | 60.3792 mL | 120.7584 mL |
| 5mM | 1.2076 mL | 6.0379 mL | 12.0758 mL | 24.1517 mL |
| 10mM | 0.6038 mL | 3.0190 mL | 6.0379 mL | 12.0758 mL |
| 20mM | 0.3019 mL | 1.5095 mL | 3.0190 mL | 6.0379 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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V1
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
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Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.