STF-62247
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $600 | Check With Us |
| 500mg | $960 | Check With Us |
| 1g | $1440 | Check With Us |
: Cat #: V2499 CAS #: 315702-99-9 Purity ≥ 98%
Description: STF-62247 is a novel potent TGN (trans-Golgi network) inhibitor with IC50 of 0.625μM and 16μM in RCC4 and RCC4/VHL cells, respectively.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 267.35 |
|---|---|
| Molecular Formula | C15H13N3S |
| CAS No. | 315702-99-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 53 mg/mL (198.2 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 3 mg/mL (11.2 mM) | |
| Solubility In Vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80: 7 mg/mL |
| SMILES Code | CC1=CC(NC2=NC(C3=CC=NC=C3)=CS2)=CC=C1 |
| Synonyms | STF-62247; STF 62247; STF62247 |
| Protocol | In Vitro | STF-62247-treated cells accumulated intracytoplasmic vacuoles characteristic of cells undergoing autophagy. Moreover, these vacuoles are larger in VHL-deficient RCC4 and SN12C-VHL shRNA cells than in wild-type VHL cells. In RCC4, RCC4/VHL, SN12C, SN12C-VHL shRNA cells, STF-62247 (0-30 μM) is selectively toxic to VHL-deficient cells compared to their VHL wild-type counterparts. |
|---|---|---|
| In Vivo | STF-62247 (2.7-8 mg/kg; intraperitoneal injection; daily; for 9 days) treatment significantly reduces tumor growth of VHL-deficient cells. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7404 mL | 18.7021 mL | 37.4042 mL | 74.8083 mL |
| 5mM | 0.7481 mL | 3.7404 mL | 7.4808 mL | 14.9617 mL |
| 10mM | 0.3740 mL | 1.8702 mL | 3.7404 mL | 7.4808 mL |
| 20mM | 0.1870 mL | 0.9351 mL | 1.8702 mL | 3.7404 mL |
The molarity calculator equation
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.