NIMODIPINE (BAY-e 9736)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$350	Check With Us
10g	$550	Check With Us
20g	$825	Check With Us

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Cat #: V1316 CAS #: 66085-59-4 Purity ≥ 98%

Description: Nimodipine (formerly BAY E 9736; BAY-E-9736, Nimotop, Periplum) is a potent dihydropyridine/DHP class of calcium channel blocker (CCB) and an autophagy inhibitor with antihypertensive effects.

References: Langley, M.S., et al. Nimodipine. Drugs 37, 669–699 (1989).

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	418.44
Molecular Formula	C21H26N2O7
CAS No.	66085-59-4
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 84 mg/mL (200.7 mM)r
	Water: < 1 mg/mLr
	Ethanol: 84 mg/mL (200.7 mM)
SMILES Code	CC1=C(C(OCCOC)=O)C(C2=CC([N+]([O-])=O)=CC=C2)C(C(OC(C)C)=O)=C(C)N1
Synonyms	BAY E 9736; BAY-E-9736, Nimodipine, Nimotop, Periplum, BAY E 9736, BAYE9736

Protocol	In Vitro	Nimodipine (1.5~150 μg/ml; 15 minutes; B16a and W256 cells) results in a dose-dependent inhibition of B16a and W256 tumor-cell-induced platelet aggregation. Nimodipine is also inhibitory in a homologous system.
Protocol	In Vivo	Nimodipine (0.2 µg/µl, intrathecal administration) prevents subarachnoid hemorrhage-associated cerebral vasospasm by prophylactic continuous intrathecal administration.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3898 mL	11.9491 mL	23.8983 mL	47.7966 mL
5mM	0.4780 mL	2.3898 mL	4.7797 mL	9.5593 mL
10mM	0.2390 mL	1.1949 mL	2.3898 mL	4.7797 mL
20mM	0.1195 mL	0.5975 mL	1.1949 mL	2.3898 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.