KAN0438757

This product is for research use only, not for human use. We do not sell to patients.

KAN0438757
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1200To Be Confirmed
200mg$1800To Be Confirmed
500mg$3035To Be Confirmed

Cat #: V32814 CAS #: 1451255-59-6 Purity ≥ 99%

Description: KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM .

References: Gustafsson NMS, et al. Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination. Nat Commun. 2018 Sep 24;9(1):3872.

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Product Promise

Promise
Molecular Weight (MW)447.43
Molecular FormulaC21H18FNO7S
CAS No.1451255-59-6
SMILES CodeO=C(OCCO)C1=CC=C(NS(=O)(C2=CC(C3=CC(F)=CC=C3O)=CC=C2)=O)C=C1O
SynonymsKAN0438757; KAN-0438757; KAN 0438757
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.2350 mL11.1749 mL22.3499 mL44.6997 mL
5mM0.4470 mL2.2350 mL4.4700 mL8.9399 mL
10mM0.2235 mL1.1175 mL2.2350 mL4.4700 mL
20mM0.1117 mL0.5587 mL1.1175 mL2.2350 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.