S29434 | CAS 874484-20-5

S29434

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$1950	Check With Us
200mg	$2925	Check With Us
500mg	$4935	Check With Us

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Cat #: V28990 CAS #: 874484-20-5 Purity ≥ 99%

Description: S29434 (NMDPEF) is a potent, competitive, selective and cell membrane-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1.

References: Boutin JA, et al. S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization. Mol Pharmacol. 2019 Mar;95(3):269-285.

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Molecular Weight (MW)	374.39
Molecular Formula	C21H18N4O3
CAS No.	874484-20-5
Synonyms	S29434; NMDPEF

Protocol	In Vitro	S29434 (5-10 μM; 24 h) induces HepG2 cells autophagy.
Protocol	In Vivo	S29434 (1 and 15 mg/kg; i.p. once) affects object recognition memory in vivo.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.6710 mL	13.3551 mL	26.7101 mL	53.4202 mL
5mM	0.5342 mL	2.6710 mL	5.3420 mL	10.6840 mL
10mM	0.2671 mL	1.3355 mL	2.6710 mL	5.3420 mL
20mM	0.1336 mL	0.6678 mL	1.3355 mL	2.6710 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.