Sinomenine

This product is for research use only, not for human use. We do not sell to patients.

Sinomenine
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5g$450Check With Us
10g$750Check With Us
20g$1125Check With Us

Cat #: V40026 CAS #: 115-53-7 Purity ≥ 99%

Description: Sinomenine, a naturally occuring alkaloid isolated from the root of the plant Sinomenium acutum, is a blocker of the NF-κB activation with anticancer and anti-inflammatory effects.

References: Song L, et al. Sinomenine inhibits breast cancer cell invasion and migration by suppressing NF-κB activation mediated by IL-4/miR-324-5p/CUEDC2 axis. Biochem Biophys Res Commun. 2015 Aug 28;464(3):705-10.

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Molecular Weight (MW)329.39
Molecular FormulaC19H23NO4
CAS No.115-53-7
SMILES Code[H][C@]1([C@@]2(C3)C4=C(O)C(OC)=CC=C4C[C@]1([H])N(C)CC2)C=C(OC)C3=O
SynonymsSinomenine; Coculine; Cucoline; Kukoline
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.0359 mL15.1796 mL30.3591 mL60.7183 mL
5mM0.6072 mL3.0359 mL6.0718 mL12.1437 mL
10mM0.3036 mL1.5180 mL3.0359 mL6.0718 mL
20mM0.1518 mL0.7590 mL1.5180 mL3.0359 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.