Sulfasalazine (NSC 667219)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50g | $480 | Check With Us |
| 100g | $800 | Check With Us |
| 200g | $1200 | Check With Us |
: Cat #: V5108 CAS #: 599-79-1 Purity ≥ 98%
Description: Sulfasalazine (NSC-667219) is an approved antiinflammatory drug used for the treatment of rheumatoid arthritis, inflammatory bowel disease such as including ulcerative colitis and Crohn's disease.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 398.39 |
|---|---|
| Molecular Formula | C18H14N4O5S |
| CAS No. | 599-79-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(O)C1=CC(/N=N/C2=CC=C(S(=O)(NC3=NC=CC=C3)=O)C=C2)=CC=C1O |
| Synonyms | NSC203730; NSC-203730 NSC 203730; Sulfasalazine; Reupirin; Rorasul; Azopyrin; NSC 667219; |
| Protocol | In Vitro | Treatment of SW620 colon cells with sulfasalazine inhibits TNFα-, LPS-, or phorbol ester-induced NFκB activation. NFκB-dependent transcription is inhibited by sulfasalazine at micro- to millimolar concentrations. TNFα-induced nuclear translocation of NFκB is prevented by sulfasalazine through inhibition of IκBα degradation. |
|---|---|---|
| In Vivo | At low doses (0.25 mM), SAS is able to suppress glioma growth by over 60% compared to untreated controls. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5101 mL | 12.5505 mL | 25.1010 mL | 50.2021 mL |
| 5mM | 0.5020 mL | 2.5101 mL | 5.0202 mL | 10.0404 mL |
| 10mM | 0.2510 mL | 1.2551 mL | 2.5101 mL | 5.0202 mL |
| 20mM | 0.1255 mL | 0.6275 mL | 1.2551 mL | 2.5101 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.