Acumapimod (BCT-197)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $730 | In Stock |
| 200mg | $1095 | In Stock |
| 500mg | $1845 | In Stock |
: Cat #: V2863 CAS #: 836683-15-9 Purity ≥ 98%
Description: Acumapimod (also known as BCT197) is a potent and orally bioavailable small molecule inhibitor of the p38 MAP kinase (MAPK-mitogen-activated protein kinase) with an IC50 of less than 1 μM for p38α.
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| Molecular Weight (MW) | 385.42 |
|---|---|
| Molecular Formula | C22H19N5O2 |
| CAS No. | 836683-15-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mMr |
| Water: <1 mg/mLr | |
| Ethanol: | |
| SMILES Code | O=C(NC1CC1)C2=CC=C(C)C(N3N=CC(C(C4=CC=CC(C#N)=C4)=O)=C3N)=C2 |
| Synonyms | BCT197A2201; Acumapimod; BCT-197; BCT197; BCT 197 |
| Protocol | In Vitro | Acumapimod is an inhibitor of p38α with an IC50 value of less than 1 μM. |
|---|---|---|
| In Vivo | Acumapimod is an oral low-molecular-weight p38 inhibitor currently in development for the treatment of several inflammatory conditions, including chronic obstructive pulmonary disease (COPD). Intermittent short-term dosing of Acumapimod (75 mg on days 1 and 6) shows a marked improvement in lung function in COPD patients. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5946 mL | 12.9729 mL | 25.9457 mL | 51.8914 mL |
| 5mM | 0.5189 mL | 2.5946 mL | 5.1891 mL | 10.3783 mL |
| 10mM | 0.2595 mL | 1.2973 mL | 2.5946 mL | 5.1891 mL |
| 20mM | 0.1297 mL | 0.6486 mL | 1.2973 mL | 2.5946 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.