Adezmapimod (SB-203580) hydrochloride

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$500	Check With Us
1g	$850	Check With Us
5g	$2150	Check With Us

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Cat #: V3639 CAS #: 869185-85-3 Purity ≥ 98%

Description: Adezmapimod hydrochloride (formerly SB-203580 HCl; SB203580; RWJ-64809; RWJ 64809) is a p38 mitogen-activated protein kinase inhibitor (p38MAPK inhibitor) with IC50 of 0.3-0.5 μM in THP-1 cells, it is 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM.

References: Davies SP, et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.

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Physicochemical and Storage Information
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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	413.90
Molecular Formula	C₂₁H₁₇ClFN₃OS
CAS No.	869185-85-3
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: N/Ar
	Water: > 8mg/mLr
	Ethanol: N/A
SMILES Code	O=S(C)C(C=C1)=CC=C1C(N2)=NC(C3=CC=NC=C3)=C2C4=CC=C(F)C=C4.Cl
Synonyms	RWJ 64809; PB 203580; SB203580; SB203580; SB 203580; RWJ-64809; PB-203580; RWJ64809; PB203580; Adezmapimod hydrochloride

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4160 mL	12.0802 mL	24.1604 mL	48.3209 mL
5mM	0.4832 mL	2.4160 mL	4.8321 mL	9.6642 mL
10mM	0.2416 mL	1.2080 mL	2.4160 mL	4.8321 mL
20mM	0.1208 mL	0.6040 mL	1.2080 mL	2.4160 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.