AK-1
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $515 | Check With Us |
| 250mg | $945 | Check With Us |
| 500mg | $1415 | Check With Us |
: Cat #: V6633 CAS #: 330461-64-8 Purity ≥ 99%
Description: AK-1 (AK1) is a novel and potent SIRT2 Inhibitor II (IC50 of 12.5 μM) with anti-Alzheimer's disease and anticancer activity.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 403.45 |
|---|---|
| Molecular Formula | C19H21N3O5S |
| CAS No. | 330461-64-8 |
| SMILES Code | O=C(NC1=CC=CC([N+]([O-])=O)=C1)C2=CC=CC(S(=O)(N3CCCCCC3)=O)=C2 |
| Synonyms | J018989; DA 42784; KB 120200; J 018989; DA-42784; KB-120200; Y1899; J-018989; DA42784; KB120200; |
| Protocol | In Vitro | AK-1 achieves significant neuroprotection in Huntington’s disease flies at 10 μM, improving the number of rhabdomeres from 5.2 to 5.6. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4786 mL | 12.3931 mL | 24.7862 mL | 49.5724 mL |
| 5mM | 0.4957 mL | 2.4786 mL | 4.9572 mL | 9.9145 mL |
| 10mM | 0.2479 mL | 1.2393 mL | 2.4786 mL | 4.9572 mL |
| 20mM | 0.1239 mL | 0.6197 mL | 1.2393 mL | 2.4786 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.