Tipiracil
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $625 | To Be Confirmed |
| 500mg | $995 | To Be Confirmed |
| 1g | $1490 | To Be Confirmed |
: Cat #: V32163 CAS #: 183204-74-2 Purity ≥ 99%
Description: Tipiracil (TPI), one of the key components in TAS-102 (trade name Lonsurf, a mixture of Trifluridine and tipiracil hydrochloride in a 1:0.5 molar ratio), is a potent thymidine phosphorylase (TPase) inhibitor with anticancer activity.
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| Molecular Weight (MW) | 242.66 |
|---|---|
| Molecular Formula | C9H11ClN4O2 |
| CAS No. | 183204-74-2 |
| SMILES Code | O=C1NC(C(C(F)(F)F)=CN1[C@@H]2O[C@H](CO)[C@@H](O)C2)=O.O=C3NC(C(Cl)=C(CN4C(CCC4)=N)N3)=O.[H]Cl |
| Synonyms | Trifluridine/tipiracil hydrochloride, TAS102, TAS-102, TAS 102 |
| Protocol | In Vitro | Tipiracil is an inhibitor of thymidine phosphorylase. Tipiracil increases trifluridine exposure by inhibiting its metabolism by thymidine phosphorylase. The combination of Trifluridine and Tipiracil is a new oral treatment for metastatic colorectal cancer. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.1210 mL | 20.6050 mL | 41.2099 mL | 82.4198 mL |
| 5mM | 0.8242 mL | 4.1210 mL | 8.2420 mL | 16.4840 mL |
| 10mM | 0.4121 mL | 2.0605 mL | 4.1210 mL | 8.2420 mL |
| 20mM | 0.2060 mL | 1.0302 mL | 2.0605 mL | 4.1210 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.