Tipiracil HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$450	Check With Us
1g	$600	Check With Us
5g	$1515	Check With Us

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Cat #: V13525 CAS #: 183204-72-0 Purity ≥ 98%

Description: Tipiracil HCl (formerly known as TPI; TAS-1-462, MA-1; trade name Lonsurf), the hydrochloride salt of tipiracil, is a thymidine phosphorylase inhibitor (TPI) approved for use in combination (TAS-102) with trifluridine for cancer treatment.

References: Peters GJ, et al. TAS-102: more than an antimetabolite. Lancet Oncol. 2012 Dec;13(12):e518-9.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	279.12
Molecular Formula	C9H12Cl2N4O2
CAS No.	183204-72-0
SMILES Code	O=C1NC(C(Cl)=C(CN2C(CCC2)=N)N1)=O.[H]Cl
Synonyms	Tipiracil HCl, TPI; TAS-102; Lonsurf; 5-CIMU; TAS-1-462, MA-1;

Protocol	In Vitro	Tipiracil has antiangiogenic effect, and inhibits proliferation of endothelial cells.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.5827 mL	17.9134 mL	35.8269 mL	71.6538 mL
5mM	0.7165 mL	3.5827 mL	7.1654 mL	14.3308 mL
10mM	0.3583 mL	1.7913 mL	3.5827 mL	7.1654 mL
20mM	0.1791 mL	0.8957 mL	1.7913 mL	3.5827 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.