Ilomastat (GM6001, Galardin)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1050 | In Stock |
| 500mg | $1650 | In Stock |
| 1g | $2475 | In Stock |
: Cat #: V0737 CAS #: 142880-36-2 Purity ≥ 98%
Description: Ilomastat (GM-6001; GM6001; Galardin), a member of the hydroxamic acid class of reversible metallopeptidase inhibitors with important biological activity, is a potent, synthetic, and broad spectrum matrix metalloprotease (MMP) inhibitor.
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- Physicochemical and Storage Information
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 388.46 |
|---|---|
| Molecular Formula | C20H28N4O4 |
| CAS No. | 142880-36-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 78 mg/mL (200.8 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 8 mg/mL (20.6 mM) | |
| SMILES Code | O=C(NC)[C@@H](NC([C@@H](CC(NO)=O)CC(C)C)=O)CC1=CNC2=CC=CC=C21 |
| Synonyms | Ilomastat; GM6001; galardin; GM-6001; GM 6001 |
| Protocol | In Vitro | Ilomastat (GM6001) inhibits human skin fibroblast collagenase, thermolysin and elastase with Kis of 0.4 nM, 20 nM, 20 nM, resepctively. |
|---|---|---|
| In Vivo | Ilomastat (GM6001) (400 μg/mL) inhibits corneal ulceration after severe alkali injury in animals. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5743 mL | 12.8713 mL | 25.7427 mL | 51.4854 mL |
| 5mM | 0.5149 mL | 2.5743 mL | 5.1485 mL | 10.2971 mL |
| 10mM | 0.2574 mL | 1.2871 mL | 2.5743 mL | 5.1485 mL |
| 20mM | 0.1287 mL | 0.6436 mL | 1.2871 mL | 2.5743 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.