Remodelin HBr

This product is for research use only, not for human use. We do not sell to patients.

Remodelin HBr
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$569Check With Us
500mg$750Check With Us
1g$1125Check With Us

Cat #: V2521 CAS #: 1622921-15-6 Purity ≥ 98%

Description: Remodelin HBr, the hydrobromide salt of Remodelin and a cell-permeable and stable analog of CPTH2, is an acetyl-transferase NAT10 inhibitor.

References: Balmus G, et al. Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome. Nat Commun. 2018;9(1):1700. Published 2018 Apr 27.

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Product Promise

Promise
Molecular Weight (MW)363.28
Molecular FormulaC15H15BrN4S
CAS No.1622921-15-6
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 72 mg/mL (198.2 mM)r
Water: <1 mg/mLr
Ethanol: <1 mg/mL
SMILES CodeN#CC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1.[H]Br
SynonymsRemodelin Hydrobromide; Remodelin HBr
ProtocolIn VitroRemodelin blocks invasion and migration of HCC cells in hypoxic conditions.
In VivoRemodelin (100 mg/kg; p.o) significantly reduces the loss of subcutaneous adipose tissue that is seen in the HGPS mouse model.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.7527 mL13.7635 mL27.5270 mL55.0540 mL
5mM0.5505 mL2.7527 mL5.5054 mL11.0108 mL
10mM0.2753 mL1.3763 mL2.7527 mL5.5054 mL
20mM0.1376 mL0.6882 mL1.3763 mL2.7527 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.