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WM-8014

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WM-8014
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Size Price Stock
250mg$990Check With Us
500mg$1650Check With Us
1g$2475Check With Us
email: [email protected]        [email protected]

Cat #: V31859 CAS #: 2055397-18-5 Purity ≥ 99%

Description: WM-8014 (WM8014; MOZ-IN3; MOZ-IN-3) is a novel, potent and prototypical inhibitor of MOZ (IC50 = 55 nM) which is a member of histone acetyltransferases with anticancer activity.

References: ARYL SULFONOHYDRAZIDES. WO2016198507 A1.

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Molecular Weight (MW)384.42
Molecular FormulaC20H17FN2O3S
CAS No.2055397-18-5
SMILES Code O=C(C1=CC(C2=CC=CC=C2)=CC(C)=C1F)NNS(=O)(C3=CC=CC=C3)=O
SynonymsWM-8014; MOZ-IN-3; WM 8014; MOZ-IN 3; WM8014; MOZ-IN3
ProtocolIn VitroWM-8014 (Compound 36) is an inhibitor of MOZ, with an IC50 of 55 nM. WM-8014 causes cell senescence and suppresses the proliferation with IC50s of 1.6 μM and 551 nM, respectively. WM-8014 also reduces mRNA coding for the MOZ gene Cdc6 by 65.1%.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.6013 mL13.0066 mL26.0132 mL52.0264 mL
5mM0.5203 mL2.6013 mL5.2026 mL10.4053 mL
10mM0.2601 mL1.3007 mL2.6013 mL5.2026 mL
20mM0.1301 mL0.6503 mL1.3007 mL2.6013 mL
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Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.