MG149
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1450 | Check With Us |
| 500mg | $2250 | Check With Us |
| 1g | $3375 | Check With Us |
: Cat #: V2520 CAS #: 1243583-85-8 Purity ≥ 98%
Description: MG-149 (MG149) is a novel, potent and selective histone acetyltransferase (HAT) inhibitor with anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 340.46 |
|---|---|
| Molecular Formula | C22H28O3 |
| CAS No. | 1243583-85-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 68 mg/mL (199.7 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: N/A | |
| SMILES Code | O=C(O)C1=C(O)C=CC=C1CCC2=CC=C(CCCCCCC)C=C2 |
| Synonyms | MG-149; MG 149; MG149; Tip60 HAT inhibitor |
| Protocol | In Vitro | MG 149 (Tip60 HAT inhibitor), at 200 μM, inhibited about 90% of Tip60 activity but had no inhibitory impact on p300 and PCAF. MG 149 was essentially competitive with Ac-CoA and noncompetitive with the histone substrate. HAT inhibition studies with MG 149 demonstrated that both compounds inhibited the HAT activity of the nuclear extracts of different regions significantly (p < 0.05). |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9372 mL | 14.6860 mL | 29.3720 mL | 58.7441 mL |
| 5mM | 0.5874 mL | 2.9372 mL | 5.8744 mL | 11.7488 mL |
| 10mM | 0.2937 mL | 1.4686 mL | 2.9372 mL | 5.8744 mL |
| 20mM | 0.1469 mL | 0.7343 mL | 1.4686 mL | 2.9372 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.