TEPP-46 (ML-265)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1050 | Check With Us |
| 500mg | $1750 | Check With Us |
| 1g | $2625 | Check With Us |
: Cat #: V4028 CAS #: 1221186-53-3 Purity ≥ 96%
Description: TEPP-46 (CID-44246499; NCGC-00186528; ML265) is a novel potent and selective small molecule activator of pyruvate kinase M2 (PKM2) with antitumor activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 372.46 |
|---|---|
| Molecular Formula | C17H16N4O2S2 |
| CAS No. | 1221186-53-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 50mg/mLr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | O=C1C(N(C)C2=C3SC(S(C)=O)=C2)=C3C=NN1CC4=CC=CC(N)=C4 |
| Synonyms | TEPP46; CID 44246499; NCGC00186528; TEPP 46; ML 265; CID44246499; TEPP-46; ML265; ML-265; CID-44246499; NCGC 00186528; NCGC-00186528; |
| Protocol | In Vitro | TEPP-46 and DASA-58 activate PKM2 by a mechanism similar to that of the endogenous activator FBP. Pre-treatment of cells with TEPP-46 or DASA-58 prevents pervanadate-induced inhibition of PKM2 activity. TEPP-46 also induces a decrease in the intracellular levels of acetyl-coA, lactate, ribose phosphate and serine. |
|---|---|---|
| In Vivo | TEPP-46 exhibits good oral bioavailability with relatively low clearance, long half-life, and good volume of distribution-parameters that predict for drug exposure in tumor tissues. TEPP-46 at 150 mg/kg readily achieves maximal PKM2 activation measured in A549 xenograft tumors. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6849 mL | 13.4243 mL | 26.8485 mL | 53.6970 mL |
| 5mM | 0.5370 mL | 2.6849 mL | 5.3697 mL | 10.7394 mL |
| 10mM | 0.2685 mL | 1.3424 mL | 2.6849 mL | 5.3697 mL |
| 20mM | 0.1342 mL | 0.6712 mL | 1.3424 mL | 2.6849 mL |
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Step Two: Enter the in vivo formulation
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Method for preparing in vivo formulation:
Take
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PEG300, mix and clarify, next add
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Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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