G150
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $2100 | To Be Confirmed |
| 200mg | $3150 | To Be Confirmed |
| 500mg | $5315 | To Be Confirmed |
: Cat #: V41626 CAS #: 2369751-30-2 Purity ≥ 99%
Description: G150 (G-150) is a novel, potent and selective inhibitor of h-cGAS (human cyclic GMP-AMP synthase) which inhibits dsDNA-triggered interferon expression with an IC50 of 10.2 nM.
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| Molecular Weight (MW) | 391.25 |
|---|---|
| Molecular Formula | C18H16Cl2N4O2 |
| CAS No. | 2369751-30-2 |
| SMILES Code | O=C(N(C1)CCC(N2)=C1C3=C2C(Cl)=C(Cl)C=C3C4=CC=C(N)N=C4)CO |
| Synonyms | G150; G-150; G 150 |
| Protocol | In Vitro | G150 (0.1-100 μM; 1 h) affects the NF-κB pathway activation in THP1-Dual cells. G150 (5-10 μM; 1 h) affects dsDNA sensing in THP1 cells and primary human macrophages. G150 (0.1-100 μM; 1 h) affects IFNB1 and CXCL10 expression in human THP1 cells and primary human macrophages. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5559 mL | 12.7796 mL | 25.5591 mL | 51.1182 mL |
| 5mM | 0.5112 mL | 2.5559 mL | 5.1118 mL | 10.2236 mL |
| 10mM | 0.2556 mL | 1.2780 mL | 2.5559 mL | 5.1118 mL |
| 20mM | 0.1278 mL | 0.6390 mL | 1.2780 mL | 2.5559 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.