YU238259
This product is for research use only, not for human use. We do not sell to patients.
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| Size | Price | Stock |
|---|---|---|
| 250mg | $950 | Check With Us |
| 500mg | $1600 | Check With Us |
| 1g | $2400 | Check With Us |
: Cat #: V14351 CAS #: 1943733-16-1 Purity ≥ 98%
Description: YU238259 (YU-238259) Is a novel and potent HDR (Homology-Dependent DNA Repair) inhibitor with anticancer activity.
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| Molecular Weight (MW) | 459.95 |
|---|---|
| Molecular Formula | C22H22ClN3O4S |
| CAS No. | 1943733-16-1 |
| SMILES Code | C1=CC(OC)=CC=C1S(=O)(=O)NCC1=CC=C(C(=O)NCCC2=CC=C(Cl)C=N2)C=C1 |
| Synonyms | YU-238259; YU238259; YU 238259; |
| Protocol | In Vitro | YU238259 is an inhibitor of homology-dependent DNA repair, with no effect on PARP activity. YU238259 shows cytotoxicity in BRCA2-deficient cells, with a low LD50 of 8.5 μM. YU238259 (0-5 μM) causes a potent, dose-dependent decrease in HDR efficiency in U2OS DR-GFP or U2OS EJ5-GFP cells, but with no effect on NHEJ frequency. YU238259 (0-10 μM) exhibits synthetic lethality with loss of frequently mutated tumor suppressors, and shows synergism with radiotherapy (IR) and DNA-damaging chemotherapy that is potentiated by BRCA2 loss. |
|---|---|---|
| In Vivo | YU238259 (3 mg/kg, i.p.) inhibits the growth of BRCA2-deficient tumor xenografts in nude mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1741 mL | 10.8707 mL | 21.7415 mL | 43.4830 mL |
| 5mM | 0.4348 mL | 2.1741 mL | 4.3483 mL | 8.6966 mL |
| 10mM | 0.2174 mL | 1.0871 mL | 2.1741 mL | 4.3483 mL |
| 20mM | 0.1087 mL | 0.5435 mL | 1.0871 mL | 2.1741 mL |
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
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Method for preparing DMSO master liquid:
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Method for preparing in vivo formulation:
Take
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DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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