GSK621
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1050 | Check With Us |
| 250mg | $2050 | Check With Us |
| 500mg | $3075 | Check With Us |
: Cat #: V0249 CAS #: 1346607-05-3 Purity ≥ 98%
Description: GSK621 is a novel, potent and selective activator of AMP-activated protein kinase (AMPK) with potential antitumor activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 489.91 |
|---|---|
| Molecular Formula | C26H20ClN3O5 |
| CAS No. | 1346607-05-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 97 mg/mL (198.0 mM)r |
| Water:<1 mg/mLr | |
| Ethanol:<1 mg/mL | |
| Solubility In Vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O: 5mg/mL |
| SMILES Code | O=C1NC2=C(N(C3=CC=C(C4=CC=CC(OC)=C4O)C=C3)C(Cl)=C2)C(N1C5=CC=CC(OC)=C5)=O |
| Synonyms | GSK-621; GSK621; GSK 621 |
| Protocol | In Vitro | GSK621 treatment also induces PERK phosphorylation, a marker of ER stress, in AML cells. GSK621 (30 μM) induces autophagy and apoptosis. GSK621 (30 μM) induces AMPKα T172, ACC (S79) and ULK1 (S555) phosphorylation. |
|---|---|---|
| In Vivo | GSK621 (30 mg/kg, ip twice daily) exhibits significant anti-tumor activity in MOLM-14 cells xenograft. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0412 mL | 10.2060 mL | 20.4119 mL | 40.8238 mL |
| 5mM | 0.4082 mL | 2.0412 mL | 4.0824 mL | 8.1648 mL |
| 10mM | 0.2041 mL | 1.0206 mL | 2.0412 mL | 4.0824 mL |
| 20mM | 0.1021 mL | 0.5103 mL | 1.0206 mL | 2.0412 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.