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Bempedoic acid (ESP55016; ETC1002)

This product is for research use only, not for human use. We do not sell to patients.

Bempedoic acid (ESP55016; ETC1002)
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Size Price Stock
100mg$400Check With Us
250mg$800Check With Us
500mg$1200Check With Us
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Cat #: V6440 CAS #: 738606-46-7 Purity ≥ 99%

Description: Bempedoic acid (formerly ESP-55016; ETC-1002; ESP55016; ETC1002; Nexletol; Bempedoate) is an ATP-citrate lyase (ACL) inhibitor as well as an activator of hepatic AMP-activated protein kinase (AMPK).

References: Pinkosky SL, et al. AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism. J Lipid Res. 2013 Jan;54(1):134-51.

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Molecular Weight (MW)344.49
Molecular FormulaC19H36O5
CAS No.738606-46-7
SMILES CodeO=C(O)C(C)(C)CCCCCC(O)CCCCCC(C)(C)C(O)=O 
SynonymsESP-55016; ESP55016; ESP 55016; Bempedoate; Bempedoic acid; ETC-1002; ETC 1002; ETC1002;
ProtocolIn VitroBempedoic acid (ETC-1002) activates AMP-activated protein kinase in a Ca2+/calmodulin-dependent kinase β-independent and liver kinase β 1-dependent manner, without detectable changes in adenylate energy charge. Bempedoic acid is shown to rapidly form a CoA thioester in liver, which directly inhibits ATP-citrate lyase.
In VivoA marked and sustained increase in AMPK and ACC phosphorylation is found in rat livers following two weeks of treatment with Bempedoic acid (ETC-1002). Bempedoic acid is >100-fold more prevalent than the CoA thioester in rat liver and is associated with AMPK activation.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.9028 mL14.5142 mL29.0284 mL58.0568 mL
5mM0.5806 mL2.9028 mL5.8057 mL11.6114 mL
10mM0.2903 mL1.4514 mL2.9028 mL5.8057 mL
20mM0.1451 mL0.7257 mL1.4514 mL2.9028 mL
The molarity calculator equation
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.