HTH-01-015 | CAS 1613724-42-7

HTH-01-015

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$1020	Check With Us
500mg	$1650	Check With Us
1g	$2475	Check With Us

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Cat #: V0250 CAS #: 1613724-42-7 Purity ≥ 98%

Description: HTH-01-015 is a novel, potent and selective inhibitor of NUAK1( (NUAK family SnF1-like kinase-1) which can serve as useful chemical probes to delineate the biological roles of the NUAK kinases.

References: Banerjee S, et al. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J. 2014 Jan 1;457(1):215-25.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	468.55
Molecular Formula	C26H28N8O
CAS No.	1613724-42-7
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 58 mg/mL (123.8 mM)r
	Water: <1 mg/mLr
	Ethanol: 30 mg/mL (64.0 mM)
SMILES Code	CC1=C(N(C)C(C2=CC(C=CC=C3)=C3C=C2N4C)=O)C4=NC(NC5=CN(N=C5)C6CCNCC6)=N1
Synonyms	HTH-01015; HTH01015; HTH 01015; HTH-01-015; HTH01-015; HTH 01-015

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.1342 mL	10.6712 mL	21.3424 mL	42.6849 mL
5mM	0.4268 mL	2.1342 mL	4.2685 mL	8.5370 mL
10mM	0.2134 mL	1.0671 mL	2.1342 mL	4.2685 mL
20mM	0.1067 mL	0.5336 mL	1.0671 mL	2.1342 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.