KY19382
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1700 | Check With Us |
| 250mg | $2850 | Check With Us |
| 500mg | $4275 | Check With Us |
: Cat #: V2448 CAS #: 2226664-93-1 Purity ≥ 99%
Description: KY-19382 is a novel, potent and orally active dual inhibitor of CXXC5-DVL( IC50s =19) and GSK3β( IC50s = 10 nM). It can be used for the research of high fat diet (HFD) induced metabolic diseases.
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- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 360.19 |
|---|---|
| Molecular Formula | C17H11Cl2N3O2 |
| CAS No. | 2226664-93-1 |
| SMILES Code | O=C1NC2=C(C=C(Cl)C(Cl)=C2)/C1=C3NC4=C(C=CC=C4)C/3=N/OC |
| Synonyms | KY19382; KY 19382; KY-1938 |
| Protocol | In Vitro | KY19382 (0.1 μM; 48 h) elevates nuclear translocation of β-catenin in ATDC5 cells. KY19382 (0.001-10 μM; 18 h) enhances the TOPFlash activity in HEK293 reporter cells. KY19382 (0.1 μM; 4 h) interrupts the CXXC5-DVL interaction in ATDC5 cells. KY19382 (0.01 and 0.1 μM; 24 h) inactivates GSK3α/β in ATDC5 cells. KY19382 (0.1 μM; 3 d) up-regulates the mRNA levels of chondrogenic differentiation markers in ATDC5 and C28/I2 cells. KY19382 (0.01 and 0.1 μM; 48 h) promotes ATDC5 cells proliferation. |
|---|---|---|
| In Vivo | KY19382 (5 mg/kg; i.p.) displays a relatively favorable bioavailability (F=16.74%), showing half-life of 16.20 h and an exposure level of 6,555.79 ng•h/ml. KY19382 (0.1 mg/kg; i.p. once daily for 10 weeks) significantly increases the length of tibiae in mice. KY19382 (0.1 mg/kg; i.p. once daily for 2 weeks) delays growth plate senescence in older mice and promotes growth plate maturation in rapidly growing young mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7763 mL | 13.8816 mL | 27.7631 mL | 55.5263 mL |
| 5mM | 0.5553 mL | 2.7763 mL | 5.5526 mL | 11.1053 mL |
| 10mM | 0.2776 mL | 1.3882 mL | 2.7763 mL | 5.5526 mL |
| 20mM | 0.1388 mL | 0.6941 mL | 1.3882 mL | 2.7763 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.