Laduviglusib (CHIR99021) trihydrochloride

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$779	Check With Us
500mg	$1070	Check With Us
1g	$1605	Check With Us

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Cat #: V3821 CAS #: 1782235-14-6 Purity ≥ 98%

Description: Laduviglusib (CHIR99021; CHIR-99021) 3HCl, the trihydrochloride salt form of CHIR-99021 (also called CT99021 or CHIR-911), is a potent and orally bioavailable GSK-3α/β (glycogen synthase kinase 3α/β) inhibitor with IC50 of 10 nM/6.7 nM in cell-free assays; CHIR-99021 was proved to promote self-renewal and maintain pluripotency of both B6 and BALB/c ES cells via stabilizing the downstream effectors like c-Myc and β -catenin.

References: Ring DB, et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	574.72
Molecular Formula	C22H21Cl5N8
CAS No.	1782235-14-6
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: > 30 mg/mLr
	Water: N/Ar
	Ethanol: N/A
Synonyms	CHIR-73911 3HCl; CHIR911; CHIR 911; GSK 3 inhibitor XVI; GSK 3IXV; CHIR99021; CHIR 99021; CT- 99021; CT-99021; CHIR73911; CHIR 73911 trihydrochloride ; CHIR-911; CT- 99021;

Protocol	In Vitro	Laduviglusib trihydrochloride inhibits human GSK-3β with Ki values of 9.8 nM.
Protocol	In Vivo	In ZDF rats, a single oral dose of Laduviglusib (16 mg/kg or 48 mg/kg) trihydrochloride rapidly lowers plasma glucose, with a maximal reduction of nearly 150 mg/dl 3-4 h after administration.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.7400 mL	8.6999 mL	17.3998 mL	34.7996 mL
5mM	0.3480 mL	1.7400 mL	3.4800 mL	6.9599 mL
10mM	0.1740 mL	0.8700 mL	1.7400 mL	3.4800 mL
20mM	0.0870 mL	0.4350 mL	0.8700 mL	1.7400 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.